The combination artemether/lumefantrine is a fixed-dose accumulation artemisinin-founded combination treatment (ACT) pointed for the therapy of chronic uncomplicated Plasmodium falciparum malaria.
Reduction in reticulocyte and leucocyte, mild GI perturbation, vomiting, abdominal pain, cardiac arrhythmia, 1st-degree heart block, transient increase in serum transaminases, dizziness, tinnitus, counts, nausea.
Drug Interactions of Artemether 80mg + Lumefantrine 480mg:
Artemether reasons in QT continuance in some patients. Thus attendant use of probucol, disopyramide, amiodarone, phenothiazines, tricyclic antidepressants, procainamide, quinidine, bretylium, bepridil, sotalol, erythromycin may be deflected.
Mechanism of action of Artemether 80mg + Lumefantrine 480mg:
Artemether is a powerful blood schizontocide, which rapidly acts and is highly effective in medicating chloroquine-resistant falciparum malaria, cerebral malaria as well as complicated falciparum malari. Its fast onset of result and advanced efficacy in bringing down the parasite loads are the attributes that make this drug an appropriate therapeutic alternative against falciparum contagion.
Metabolism: Quickly hydrolyzed to the active substance dihydroartemisinin. Excretion: Removal half-life: about 4-11 hr after oral admin.
Particular Precautions for Artemether 80mg + Lumefantrine 480mg:
Avoid concomitant usage of medicates known to extend QT time interval or monitor such affected person.
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